Humor in the police logs

For a long time I have made a habit scanning the Palo Alto’s Daily Post for a few laughs. It’s not the comics page I’m looking at–it’s the Police Blotter. They have it broken down by city, and while most cities are afflicted by regular burglaries, assaults and vandalism, Atherton’s police reports seem to come from a parallel universe. Police rolled on these actual cases recorded in the Police Blotter from the April 25 Daily Post:

Friday, 1:59 AM – Two small dogs got loose at Middlefield and Holbrook and were last seen headed southbound. Police were unable to locate them.

9:16 PM – A group of juveniles were heard talking loudly on the swing set at Laurel School. Officer contacted the family, who said they were just leaving.

Saturday, 8:27 AM – Gardeners on De Bell Drive warned they were working prior to the time allowed for such activity.

In the past I have seen such reports as: Suspicious person reported near a house. Police investigated and found it to be the cable installer. Even though I find the police calls humorous, at the same time I wish every peninsula city were like that.

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Drinking the fog

In Santa Cruz, where I grew up, the fog rolls in every summer evening and burns off about noon the next day, so this story about the technology to catch fog for drinking water was particularly interesting to me. Santa Cruz is now looking at desalinization plants to fulfill future water needs, but I wonder if a system to collect the water in fog might really be a cheaper and more energy-efficient system. The redwoods have been doing well with such a system for millions of years.

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The smell of remembering

There was a time in the 60s when various people promised you could learn in your sleep. Just play a tape of a lesson as you slept, and voila! you would be ready to ace the test in the morning. Needless to say, it didn’t work.

But at the Sleep Grand Rounds at Stanford recently I did hear about a method of sleep learning that does work. Technically it is sleep remembering, rather than sleep learning, but it is just as valuable.

We already know that sleep is very important in consolidating memories. People who deprive themselves of sleep to study will not remember something as well as someone who has had a good night’s sleep. What this researcher also showed, at least in mice, was that if the mice were exposed to a scent (rose, in this case) while they learned a task, and then had the rose scent in their cages while they slept, they would remember what they learned far better than those mice that did not get the sleep scent. This was true not only for positive learning (a sequence of moves that produces a reward) but also for aversive learning (a tone followed by a slight shock). My assumption is that the scent put the brain in the same frame as it occupied while learning, so the things that were learned are at the head of the line to be solidified in long-term memory.

So put some perfume in front of you while you learn and then again while you sleep (but use that scent for nothing else), and it will help solidify your learning.

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Birds and humans are the only animals that gotta’ dance

An interesting interview from Discover, about how nearly every species except humans can’t learn to bop to the beat of music. As the researcher explains, this probably has to do with our vocal learning pathways, which have to be highly attuned to subtle sound rhythms.

“One theory is that music promoted group bonding when people danced together, and that in turn promoted the survival of groups. The counterargument is that maybe our sense of musical rhythm is just a by-product of another cognitive function that gave us an advantage. But what other function could that be? In 2006 I wrote a paper suggesting that rhythm could be a by-product (pdf) of another function that requires us to tightly integrate sound and movement: vocal learning, or the ability to mimic sounds made by other individuals. That led to the hypothesis that you need a vocal-learning brain to be able to move to a beat. The implication is that dogs and cats can never do it, horses and chimps can never do it, but maybe other vocal-learning species can do it.”

The only other species (class, technically) that can learn to move in rhythm to music turns out to be birds, which also learn and communicate through complex sounds.

 

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To Lose Weight: Learn to Be Hungry

It sounds like a joke: if you want lose weight, go hungry. But I’m serious. A lot of the obesity we see exists because our bodies have forgotten how to be hungry.

We are designed to fast occasionally. Our bodies are tuned to put on weight in times of plenty and burn fat in lean times. Not only has modern society supplied us with a fairly reliable supply of food (generally a good thing), we also have constant access to snacks, candies, cookies, and (perhaps worst of all) sugared drinks like soft drinks, coffee, tea or even fruit juices. So we are almost never really hungry. At the first sign of hunger, most people grab a little something. We do this mostly without thinking throughout the day.

The result is that the body “forgets” how to deal with a drop in blood sugar. Try a little experiment with yourself: After breakfast, don’t eat anything at all. Try to see how long you can go. Observe your own reactions. Most people will start to feel hungry, then anxious, then shaky and/or cold. You may grab a snack out of habit and have it in your mouth before you know what you are doing. Finally, it becomes hard to think of anything other than your hunger. I remember that when I tried this experiment the first time I had to consciously remind myself that what felt like dread was just hunger, which wasn’t going to kill me (not in one day), and that the anxiety I felt was not a forewarning that something bad was going to happen.

Your body can be trained out of this. There are parallels in exercise. When I started running again after not doing much for exercise for years, I could barely go a mile. But as I kept doing it day after day, all the  systems in my body started to tune up and learn how to process energy and move muscles efficiently.

In the same way, skipping all snacking is hard at first because the systems that mobilize body fat for energy have become inefficient. The body has come to rely on a regular supply of carbohydrates or fats from the outside. It doesn’t know how to deal with falling insulin levels. It probably even overreacts because, as a result of the constantly high levels of insulin, it has down-regulated the activity of the insulin receptors (and over years this down-regulation leads to insulin insensitivity and type 2 diabetes). But as you eat less often, and eat smaller meals, the body adapts. Just as with exercise, the more you do it the easier it is. And you are living more in line with the way our bodies were designed by evolution to function. And when the body needs some energy, it starts pulling from the fat stores it has squirreled away for exactly this purpose, without bothering the mind much at all.

I think people might have an easier time with dieting if they saw it not as deprivation, but as active training to strengthen the metabolic machinery.

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How to get yourself to exercise more

I find that when I first start a run I can sometimes feel like a steaming pile of dog poo, especially if I have been away from running for a bit. But I also know that if I keep on going, the lousy feeling usually goes away and I start feeling a lot better.

This study, by way of the blog Barking up the Wrong Tree, demonstrates that a lot of people feel that way, and that people consistently underestimate how much they will enjoy exercise because they focus too much on that first, hard part. In other words, when people are asked beforehand how much they will enjoy exercising, and then afterward are asked how much they actually enjoyed it, they usually liked it more than they imagined.The authors call this “forecasting myopia.”

The authors say this gets in the way of exercise, and that people can increase their motivation to exercise if they consciously place more emphasis on the later stages of exercise.

A pro runner once told me that everyone –everyone–hates to begin the run, but that serious runners get out and do it anyway. That sometimes helps me get past my own resistance and hit the road. The other thing that works for me is to make a conscious effort at the and of the run to just soak up and remember that good feeling, knowing that if I don’t I’m likely to forget.

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Dopamine and Serotonin: Words and Music

Serotonin has sometimes been called the “police officer” of the brain, regulating the action of other neurotransmitters like dopamine. But this seems to me to be not quite the right analogy. I think of serotonin as the mood music of the brain.

Originally, serotonin was a signal from the gut to the muscles that said, “Whoa, slow down.” When the roundworm C. elegans is on top of a beautiful lawn of yummy bacteria, serotonin produced in the gut says “sit back and stay a while, this here’s good eatin’.” As evolution advanced, serotonin was used in the brain to signal that things were generally kopacetic, that you not only have good food, but good friends, enough gold in your pocket, and it looks like it’s going to be a beautiful day. A lack of dopamine would be the signal that there are clouds on the horizon, the friends are getting surly, and it’s time to move along to greener pastures.

Serotonin sets the mood by which other neurotransmitter signals will be interpreted. Try watching a scary movie with the sound turned down and some amusing music turned on. It’s not so scary anymore. This is like having a lot of serotonin. But now think of movie scenes of an empty dining room, a bedroom with the beds made and flowers on the nighstand, and add the soundtrack from Jaws, Psycho or some other scary movie. Now those innocent scenes seem ominous. Something bad is going to happen. Things look a little too perfect in this house. That’s the condition when there isn’t enough serotonin (or the receptor is not as effective).

Dopamine is like the words of a song, signalling “hey that’s good, do that again,” but serotonin is like the music that conveys the mood. Even if the words are positive, if the music is discordant, they are going to feel off.

Evolution seems to spend a lot of time tinkering to get the right mix of serotonin. Too much and we become such a sunny optimist that when we see a lion we want to pet the kitty. Things seem so awesome that we just want to lie on our backs and look at the sky, even when in reality our food supply is running out and winter is coming on. Que sera, you know? A little less serotonin and we are worried about how we are going to get breakfast tomorrow. A little less than that and we are worried about how we are going to get breakfast next month. And things just don’t seem right unless the knots in our shoelaces are tied perfectly, with evenly sized loops. In other words, we are little neurotic. Less serotonin than that and we get depressed–nothing seems right–and ultimately we are back to sitting around and staring at the sky, only this time it’s because every option for action looks so bad.

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Digital technologies and social networks will usher in the biggest shakeup medicine has ever seen

Yesterday, Eric Topol, who is director of the Scripps Translational Science Institute in La Jolla, CA,  spoke to members of the Stanford Cardiovascular Institute about the transformative power of digital technology and social networks in medicine. He noted that the Economist Joseph Schumpeter described over 50 years ago how old ways of doing things are destroyed as new technologies take over.

 “Medicine is about to go through the biggest shakeup in history,” Topol predicted. “We are about to get Schumpetered.”

Displaying a graph of people’s increasing interaction with digital devices, he talked about the rise of the iPod, the Blackberry phone, the iphone and now social networking and the accelerating changes they have made in how we live our lives. Add those devices to the increasing amount of digital information available about our biological and physiological states, and “we are about to hit the inflection point” in how all medicine is done.

Topol foresees a world in which people will be able to know an enormous amount about their own genes, biochemistry and physiological state, will be able to monitor changes in real time and transmit that information to physicians far away. There are already wireless devices that record and transmit information about blood pressure, heart rate, physical activity and sleep state. Doctors can carry an echocardiogram device in their pockets. Very soon, Topol says, we will have inexpensive implanted sensors that will be able to spot cancer cells floating in the bloodstream or spot a developing heart attack, giving us enough warning to do something about it.

The new technology will let many people be at home instead of in the hospital because they can be monitored from afar. “Why do we need hospitals except for intensive care visits?” Topol says. “Why do we need clinics when we can do it wirelessly?”

Putting these information technologies to work will also finally allow medicine to move from a populations-based approach to individualized medicine. As an example, Topol cited the case of Nicholas Volker, who at three years old had undergone more than 100 operations because a mystery illness was eating away at his digestive tract. As a last resort, they sequenced his whole genome and found one gene mutation that was causing the problem. A stem cell transplantation from cord blood cured him.

I for one am looking forward to these changes. I think they will result in a system in which we are more connected to our health needs, more connected to people around us, and generally better healthcare (as long as we don’t lose the personal connection to physicians).

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Alcohol helps the brain remember

I’m going to skip to what I found most remarkable about this news release from the Waggoner Center for Alcohol and Addiction Research at The University of Texas at Austin:

“People commonly think of dopamine as a happy transmitter, or a pleasure transmitter, but more accurately it’s a learning transmitter,” says (researcher Histoshi) Morikawa. “It strengthens those synapses that are active when dopamine is released.”

To me, this is a nice description of my strengthening view about the relationship between pleasure and learning.

To backtrack a little, this researcher is saying that alcohol can interfere with conscious remembering, but it actually assists in the development of unconscious learning. Alcoholism is being increasingly seen as a disorder of learning and memory. Another key quote:

“In an important sense, says Morikawa, alcoholics aren’t addicted to the experience of pleasure or relief they get from drinking alcohol. They’re addicted to the constellation of environmental, behavioral and physiological cues that are reinforced when alcohol triggers the release of dopamine in the brain.”

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Some stats on ebooks and ereaders

I knew that Amazon was now selling more Kindle books than paper books, but I was interested to see that ebook sales overtook hardcover sales this year.

E-book sales, January 2011: $69.9 million
E-book sales, January 2010: $32.4 million
Hardcover sales, January 2011: $49.1 million
Hardcover sales, January 2010: $55.4 million
Percentage of Americans who read e-books: 7 percent
E-reader shipments worldwide, fourth quarter 2010: 5.1 million units
E-readers in use by end of 2011, estimated: 10.3 million
Number of titles available for Amazon’s Kindle e-reader today: 850,000
Number of titles available for Amazon’s Kindle e-reader one year ago: 630,000

(From the San Jose Mercury News)

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